narasin

Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by suppressing the phosphorylation of IκBα.

Narasin is a polyether ionophore antibiotic with established antimicrobial activity and reported potential antiviral and anticancer effects in experimental studies. Narasin has been shown to inhibit NF-κB signaling and induce apoptosis in tumor cells, and may suppress tumor metastasis and the growth of ERα-positive breast cancer cells by modulating TGF-β/SMAD3 and IL-6/STAT3 signaling pathways

20-Deoxynarasin exhibits activity against Gram-positive bacteria, mycoplasma, coccidia, and viruses, and it also promotes growth.