mutase

L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.

PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).

HKB99 is a mutant inhibitor of phosphoglycerate mutase 1 (PGAM1), which inhibits the growth and metastasis of non-small cell lung cancer.HKB99 acts synergistically with EGFR inhibitors and assists in the killing of tumors by EGFR inhibitors.HKB99 promotes oxidative stress, which induces alterations in a variety of signaling pathways.HKB99 can be used in the study of metabolism-related diseases.HKB99 can be used in the study of metabolism-related diseases.HKB99 can be used in the study of metabolism-related diseases.

LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.

Phosphoglucomutase promotes cyst development in Toxoplasma gondii. Deficiency of Phosphoglucomutase causes metabolic disorders.

Superoxide dismutase (SOD), an enzyme that alternatively catalyzes the disproportionate decomposition of superoxide anion radicals (O2-) to O2 and H2O2, is an important antioxidant defense mechanism that effectively reduces pro-inflammatory cytokines and inhibits neutrophil infiltration into sites of tissue damage.

Manganese Superoxide Dismutase (Mn SOD) is an antioxidant enzyme located within mitochondria that catalyzes the dismutation of superoxide radicals (O2·-) into oxygen (O2) and hydrogen peroxide (H2O2). Mn SOD plays a crucial role in protecting cells from oxidative damage and is involved in conditions such as transplant rejection, neurodegenerative diseases, cardiovascular diseases, and cancer.

Cu/Zn Superoxide dismutase (Cu/ZnSOD; SOD1) is a cytoplasmic copper-zinc dimeric form of superoxide dismutase. It functions by catalyzing the dismutation of superoxide radicals.

Superoxide dismutase PEG (EC 1.15.1.1) is an analog of superoxide dismutase (SOD) and acts as a potent free radical scavenger by reducing superoxide anions.

Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.

EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities and inhibits the formation of β-amyloid and related amyloid fibrils.

Manganese(salen) chloride (EUK-8) is a superoxide dismutase and catalase mimetic, serving as an antioxidant with oxyradical scavenging properties, and ameliorates acute lung injury in endotoxemic swine.

Adenosylcobalamin (AdoCbl) is a biologically active form of vitamin B12 .It is a cofactor for methylmalonyl CoA mutase. It belongs to the corrinoid group of compounds, which contain a corrin macrocycle, and is produced only by certain bacteria and archaea. It is a cofactor for various enzymes including mutases, eliminases, aminomutases, and a reductase.

Enasidenib mesylate (AG-221 mesylate) is a potent and selective IDH2 mutase inhibitor that promotes differentiation of leukemia myeloid cells for the treatment of acute myeloid leukemia.

PGAM1-IN-1 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC50 of 6.4 μM [1].

PGAM1-IN-2 is an inhibitor of phosphoglycerate mutase 1 ( PGAM1 ) with an IC 50 of 2.1 μM [1].

MJE3 is an inhibitor of phosphoglycerate mutase-1 (PGAM1), it displays antiproliferative effects in human breast cancer cells by inhibiting glycolysis.

1-Deaza-fad also known as Deazafad. 1-deazaFAD has comparable activity in the mutase reconstituted.

Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such asM. extorquens, which uses this pathway when grown on ethylamine.1,2It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA. 1.Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al.Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1J. Bacteriol.197(4)727-735(2015) 2.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011)

Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011) 2.Tabita, F.R.The hydroxypropionate pathway of CO2 fixation: Fait accompliProc. Natl. Acad. Sci. U.S.A.106(50)21015-21016(2009) 3.Medicine, I.o.Vitamin B12Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline306-356(1998) 4.Cardinale, G.J., Carty, T.J., and Abeles, R.H.Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B12 deficiency, on fatty acid synthesisJ. Biol. Chem.245(15)3771-3775(1970)

UGM-IN-3 (compound 10a) is an inhibitor of UDP-galactopyranose mutase (UGM) with a Kd of 66 μM and inhibits the growth of Mycobacterium tuberculosis (MIC= 6.2 μg/mL).

Methylmalonyl coenzyme A (Methylmalonyl-CoA) is a metabolic product derived from the breakdown of odd-chain fatty acids, cholesterol, and certain amino acids, such as valine, isoleucine, methionine, and threonine. It is enzymatically converted into succinyl-CoA through the action of methylmalonyl-CoA mutase (MCM) utilizing coenzyme vitamin B12.

Methylmalonyl-CoA tetralithium, also known as Methylmalonyl coenzyme A, serves as a metabolic byproduct derived from the breakdown of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. It is converted into succinyl-CoA through the enzymatic activity of methylmalonyl-CoA mutase (MCM) in the presence of the coenzyme vitamin B12 [1].