mouse neutrophil elastase

FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef

SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase, displaying higher affinity for human elastase (Ki = 0.0168 nM) compared to rat (Ki = 3 nM), mouse (Ki = 1.8 nM), and rabbit (Ki = 58 nM) elastases [2]. It reduces myocardial infarct size following ischemia-reperfusion injury [1] and has potential for treating chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis, and various inflammatory diseases.

Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway. It can be used in acute lung injury/acute respiratory distress syndrome research.

KRP-109 is a neutrophil elastase (NE) inhibitor known for its ability to alleviate lung inflammation. In mouse models, KRP-109 has been shown to increase survival rates and reduce both the number of neutrophils in alveolar walls and the severity of inflammation. It significantly decreases cell and neutrophil counts, along with cytokine levels (such as interleukin 1β and macrophage inflammatory protein 2) in bronchoalveolar lavage fluid. KRP-109 is applicable for investigating severe pneumonia.