mots-c(human) acetate

MOTS-c(Human) Acetate is a mitochondrial-derived peptide. MOTS-c(human) acetate induces the accumulation of AMP analog AICAR, increases activation of AMPK and expression of its downstream GLUT4. MOTS-c(human) acetate induces glucose uptake and improves insulin sensitivity. MOTS-c(human) acetate has implications in the regulation of obesity, diabetes, exercise, and longevity.

MOTS-c, mouse is a mitochondrial-derived peptide involved in the regulation of pancreatic cell function. It reduces insulin secretion and expression in INS-1E cells while enhancing glucagon secretion and expression in αTC-1 cells. Additionally, MOTS-c, mouse decreases apoptosis in both INS-1E and αTC-1 cells and counteracts diet-induced obesity and insulin resistance by activating AMPK.

MOTS-c is a mitochondria-derived polypeptide (MDP) that has anti-damage and anti-inflammatory effects by activating the AMPK pathway and inhibiting the MAP kinase-c-fos signaling pathway.