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(2)
By Target- Apoptosis
- Casein Kinase(1)
- DNA/RNA Synthesis(1)
- Dehydrogenase(1)
- FLT(1)
- Molecular Glues(1)
- PROTACs(1)
- STAT(1)
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Results for "
molm-14
" in TargetMol Product Catalog- Inhibitors & Agonists9
- PROTAC Products3
PROTAC METTL3 degrader 1
T200771
PROTAC METTL3 degrader 1 (Compound KH12) is a VHL-based degrader of METTL3, demonstrating a DC50 of 220 nM in MOLM-13 cells. This compound inhibits the METTL3 14 complex with an IC50 of 341 nM and exhibits antiproliferative activity against AML cells.
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JCS-1
T203316
JCS-1 is a potent DcpSPROTAC degrader. It non-covalently binds to DcpS via an RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 facilitates the ubiquitination and degradation of DcpS at nanomolar concentrations, with a DC50 of 87 nM in MOLM-14 cells. This compound can be utilized in research on acute myeloid leukemia and other DcpS-dependent genetic disorders.
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