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By Target- Histone Methyltransferase
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Results for "
mm102
" in TargetMol Product Catalog- Inhibitors & Agonists2
MM-102
Cited
MM102, HMTase Inhibitor IX
T63331417329-24-8
MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5 MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay. MM-102 can also specifically inhibit cell growth and induce apoptosis in leukemia cells carrying MLL1 fusion protein.
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CitedMM-102 TFA
HMTase Inhibitor IX TFA
T87681883545-52-5
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5 MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos.
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