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By Target- Apoptosis
- Aurora Kinase(1)
- Autophagy(1)
- Others(1)
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Results for "
mln-8237
" in TargetMol Product Catalog- Inhibitors & Agonists2
Alisertib
MLN 8237
T22411028486-01-2
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.
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Alisertib sodium
MLN 8237 sodium
T384281028486-06-7
Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle, causing abnormal cell division. At the molecular level, it acts on the AKT mTOR AMPK p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells, and exhibits significant antitumor activity.
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