ml-335

ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor) DOR (δ-opioid receptor) heterodimer, with anti-injury sensory activity and pain inhibitory activity.

ML335 is a selective activator of TREK-1 and TREK-2.

Poloxamer 335 P105 is a block copolymer composed of polyoxyethylene and polyoxypropylene, with an average molecular weight of 6500. At a concentration of 1 mg mL, it exhibits antibacterial properties by inhibiting 86% of Mycobacterium avium. Meanwhile, Poloxamer 334 P104 has muscle toxicity and forms thermoreversible hydrogels, making it useful as a food additive and a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering.