ml-133

ML133 is a selective inhibitor of the Kir2 family of channels, exhibiting an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.

ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

Antifungalagent 133 (compound D2) is an orally active antifungal compound with an MIC80 value of 0.13 µg/mL against C. neoformans H99. It is suitable for research on cryptococcal meningitis.

YM 133 (IMC-XV) is a semi-synthetic macrolide antibiotic with potent bactericidal activity. It is effective against strains of staphylococci, streptococci, Bacteroides, and Clostridia that are resistant to erythromycin, josamycin, and rokitamycin (MIC≥ 100 μg/mL). Additionally, YM 133 exhibits excellent activity against macrolide-resistant strains and anaerobic bacteria, making it valuable for antibacterial research.

Fibrinogen γ-chain (117-133) is a selective inhibitor of intercellular adhesion molecule-1 (ICAM-1), with an IC50 of approximately 20-40 μg/mL. It can block fibrinogen-mediated adhesion of monocytes to endothelial cells and shows potential for research in thrombo-inflammatory diseases, such as atherosclerosis and organ transplant rejection.