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(2)
By Target- Aurora Kinase
- Autophagy(1)
- PROTACs(1)
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Results for "
mk-5108
" in TargetMol Product Catalog- Inhibitors & Agonists2
- PROTAC Products1
MK-5108
VX-689, MK5108
T60681010085-13-8
MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.
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JB300
T2042233038446-90-8
JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.
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