mitochondrial cytochrome bc1

Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals' resistance in the pathogenic fungus Candida albicans.

Inz-5 is a small-molecule inhibitor of the mitochondrial electron transport chain that selectively targets mitochondrial complex III (cytochrome bc1 complex), disrupting the process of oxidative phosphorylation and reducing ATP production. It is commonly used in studies of mitochondrial energy metabolism, fungal respiration, and mechanisms related to the electron transport chain. Inz-5 exhibits antifungal activity against a variety of fungal pathogens, demonstrating particularly strong inhibitory effects against Candida species associated with candidiasis; in some studies, its minimum inhibitory concentration (MIC) against Candida albicans reached the sub-micromolar range (approximately 0.5 μM). Furthermore, as an inhibitor of mitochondrial oxidative phosphorylation, Inz-5 is also used to study mechanisms related to tumor cell metabolism and mitochondrial function.

Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.

ELQ-453 is an inhibitor that targets the Qo site of the cytochrome bc1 complex (CytB) in the malignant Plasmodium falciparum, with an IC50 value of 0.57 μM. ELQ-453 disrupts mitochondrial function in parasites and prevents Plasmodium infection in mosquitoes, showing promise for malaria research.

GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum.

Inz-4 is a fungal-selective inhibitor of mitochondrial cytochrome bc1.