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- VEGFR(1)
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Results for "
microvasculature
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Peptide Products2
- Recombinant Protein2
- Disease Modeling1
Semaxinib
Cited
SU5416
T2064204005-46-9
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.
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