miconazole

Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion.

Miconazole nitrate (R18134 nitrate), an imidazole antifungal agent, selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.

Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis.

Fluconazole (hydrate) is a triazole antifungal agent used for oral treatment and prevention of both superficial and systemic fungal infections, including but not limited to balanitis, various Candida infections, Cryptococcus infections, dermatomycosis, and fungal infections of the respiratory and urinary tracts. As the hydrate salt form of fluconazole, it exhibits antifungal activity by inhibiting the growth and development of pathogenic fungi, such as Candida species, at minimal inhibitory concentrations often exceeding 100 mg l. Notably, it disrupts the branching and hyphal formation in C. albicans at concentrations as low as 0.3 mg l, indicating its potency compared to other antifungals like miconazole and ketoconazole which are effective at 100-fold lower concentrations. Clinical studies have not shown a significant increase in the risk of most birth defects with oral fluconazole, although there may be an associated risk of tetralogy of Fallot. Its efficacy against Cryptococcus gattii in koalas suggests it may be ineffective as a sole therapeutic agent at a dosage of 10 mg kg orally every 12 h. Toxicity symptoms from overdose can include hallucinations and paranoid behavior.

Eberconazole, a dichlorinated imidazole derivative, exhibits antifungal activity and outperforms Clotrimazole, Ketoconazole, and Miconazole in efficacy. It holds promise for dermatophytoses research through topical administration.

Antifungal agent 54 (compound A05) is a potent inhibitor against Fluconazole-resistant strains, outperforming Miconazole in efficacy. It exhibits significant activity against Candida albicans, with minimum inhibitory concentration (MIC) values ranging from 0.25-1 μg mL [1].

Antifungal agent 55 (Compound A07) effectively inhibits Fluconazole-resistant strains of Candida albicans, demonstrating greater efficacy than Miconazole. It exhibits minimum inhibitory concentrations (MIC) values ranging from 0.25-1 μg mL [1].

Antifungal agent 56 (compound A09) is a potent antifungal, demonstrating superior efficacy against Fluconazole-resistant strains and outperforming Miconazole, effectively inhibiting Candida albicans strains with minimal inhibitory concentration (MIC) values ranging from 0.03 to 0.25 μg mL [1].

Antifungal Agent 57 (Compound A19) demonstrates potent efficacy against Fluconazole-resistant strains, outperforming Miconazole. It effectively inhibits Candida albicans strains, exhibiting minimum inhibitory concentrations (MIC) ranging from 0.5 to 2 μg mL [1].

Antifungal agent 58 (compound A21) demonstrates high potency against Fluconazole-resistant strains and surpasses Miconazole in effectiveness, inhibiting Candida albicans with minimum inhibitory concentration (MIC) values ranging from 0.06 to 8 μg mL [1].

Eberconazole Nitrate (Ebernet) is an azole antifungal agent and broad-spectrum imidazole derivative.