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Results for "
marcfortine a
" in TargetMol Product Catalog- Inhibitors & Agonists1
Marcfortine A
T3574575731-43-0
Marcfortine A, an indole alkaloid originally isolated from P. roqueforti, exhibits nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg ml) and inhibits motility of adult worms (EC50 = 2 μM). It effectively eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg animal, respectively). Marcfortine A also dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
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