mal-peg1-acid

Mal-PEG1-acid is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal is a lysine amino acid derivative with a maleimide group at the C-terminus. The α-amino group is protected by a Boc group, and the ε-amino group is capped with an amide-PEG1-t-butyl ester. The maleimide group is a thiol-reactive covalent moiety for attaching to cysteine residues, while the Boc and t-butyl ester groups can be deprotected for subsequent reactions.

N-(PEG1-acid)-L-Lysine-amido-Mal is a PEG-based linker featuring terminal maleimide and carboxylic acid groups. The hydrophilic PEG spacer enhances solubility in aqueous media. The maleimide group covalently reacts with thiol groups, facilitating biomolecule-thiol conjugation. The terminal carboxylic acid can form a stable amide bond with primary amines in the presence of activators (e.g., EDC or HATU).