m-281

Nipocalimab (M281) is a fully humanized anti-FcRn monoclonal antibody that can be used to study systemic myasthenia gravis and rheumatoid arthritis.

Relamorelin(BIM28131, RM131) is a selective and potent ghrelin/growth hormone secretagogue receptor (GHSR) agonist with high affinity for GHS-1a receptor (Ki value is 0.42 ± 0.063 nM). Relamorelin(BIM28131, RM131) is also a centrally permeable pentapeptide analog that can increase growth hormone levels and accelerate gastric emptying, and has the potential to study cachexia.

AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.

Relamorelin (RM-131) acetate is a pentapeptide ghrelin analog that acts as a selective agonist for the ghrelin/growth hormone secretagogue receptor (GHSR). It exhibits a high affinity for the GHS-1a receptor, with a Ki value of 0.42 nM. Notably, Relamorelin acetate can cross the blood-brain barrier and target the central nervous system. This compound effectively increases growth hormone levels and promotes faster gastric emptying. Due to these properties, Relamorelin acetate holds promise for its potential applications in research related to cachexia, gastroparesis, and gastric/intestinal dysmobility disorders [4] [5].

YM281, a potent EZH2 inhibitor, promotes cell apoptosis and induces cell cycle arrest at the G0/G1 phase, demonstrating antitumor effects in vivo. This compound holds promise for lymphoma research [1].

Narcissin (Standard) is a reference standard for research and analysis in studies involving Narcissin. Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress.

Narciclasine (Standard) is a reference standard for research and analysis in studies involving Narciclasine. Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.

Salicin (Standard) is a reference standard for research and analysis in studies involving Salicin. Salicin (Salicine), a phenol β-glycoside produced from willow bark, shows anti-inflammatory functions.

Methyl salicylate (Standard) is a reference standard for research and analysis in studies involving Methyl salicylate. Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments.

Withanoside IV (Standard) is a reference standard for research and analysis in studies involving Withanoside IV. Withanoside IV is a natural product for research related to life sciences. The catalog number is TN5260 and the CAS number is 362472-81-9.

Withanoside V (Standard) is a reference standard for research and analysis in studies involving Withanoside V. Withanoside V is a natural product for research related to life sciences. The catalog number is TN5261 and the CAS number is 256520-90-8.

Withanolide A (Standard) is a reference standard for research and analysis in studies involving Withanolide A. Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

Withanolide B (Standard) is a reference standard for research and analysis in studies involving Withanolide B. Withanolide B, a natural product isolated from Withania somnifera Dunal, promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) via the ERK1/2 and Wnt/β-catenin signalling pathways, thereby enhancing bone healing. Withanolide B exhibits affinity for the catalytic domain of PARP-1.

(±)-Isomenthone (Standard) is a reference standard for research and analysis in studies involving (±)-Isomenthone. (±)-Isomenthone is a racemic, optically active compound primarily employed in determining optical activity [1].

Gypsogenin-3-O-glucuronide (Standard) is a reference standard for research and analysis in studies involving Gypsogenin-3-O-glucuronide. 1. Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) shows inhibitory activity toward pancreatic lipase with IC5 value of .29 mM, and the free carboxylic acid groups in position 28 within its chemical structures are required for enhancement of pancreatic lipase inhibition.

Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a concentration of 100 μM.3 Dietary administration of collinin (0.05% w/w) reduces the number of mice with tumors and the number of tumors per mouse in a mouse model of colitis-related carcinogenesis.4 |1. Kim, S., Seo, H., Al Mahmud, H., et al. In vitro activity of collinin isolated from the leaves of Zanthoxylum schinifolium against multidrug- and extensively drug-resistant Mycobacterium tuberculosis. Phytomedicine 46, 104-110 (2018).|2. Nguyen, P.-H., Zhao, B.T., Kim, O., et al. Anti-inflammatory terpenylated coumarins from the leaves of Zanthoxylum schinifolium with α-glucosidase inhibitory activity. J. Nat. Med. 70(2), 276-281 (2016).|3. I.S., C., Lin, Y.C., Tsai, I.L., et al. Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium. Phytochemistry 39(5), 1091-1097 (1995).|4. Kohno, H., Suzuki, R., Curini, M., et al. Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int. J. Cancer 118(12), 2936-2942 (2006).