m-199

M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.

Pyrazosulfuron-ethyl (Standard) is the standard substance of Pyrazosulfuron-ethyl, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyrazosulfuron-ethyl a sulfonylurea herbicide for the control of broadleaf weeds, grasses and sedges in rice, acts by inhibiting ALS (acetolactate synthase).

Pyrene-d10 (Standard) is the standard substance of Pyrene-d10, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyrene-d10 is a deuterated compound of Pyrene. Pyrene has a CAS number of 129-00-0.

Pyribencarb (Standard) is the standard substance of Pyribencarb, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyribencarb, a benzylcarbamate-type fungicide, exhibits broad-spectrum activity against various plant pathogenic fungi. Acting as a potent Qo inhibitor of cytochrome b, Pyribencarb demonstrates particular efficacy against Botrytis cinerea and Sclerotinia sclerotiorum.

Pyributicarb (Standard) is the standard substance of Pyributicarb, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Pyridate (Standard) is the standard substance of Pyridate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyridate is mainly used as a selective post seedling herbicide.

Astragaloside II (Standard) is a reference standard for research and analysis in studies involving Astragaloside II. Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, proliferation, and mineralization, through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways.

Pyridoxal hydrochloride (Standard) is the standard substance of Pyridoxal hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. The 4-carboxyaldehyde form of vitamin B6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.

Astragaloside III (Standard) is a reference standard for research and analysis in studies involving Astragaloside III. Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant.

Pyridoxine hydrochloride (Standard) is the standard substance of Pyridoxine hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin. [Matreya, LLC. Catalog No. 1321] 1.Ito, M., Kurita, T., and Kita, K.A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycosphingolipids as well as sphingomyelin to produce their lyso formsJ. Biol. Chem.270(41)24370-24374(1995) 2.Nixon, G.F., Mathieson, F.A., and Hunter, I.The multi-functional role of sphingosylphosphorylcholineProg. Lipid Res.47(1)62-75(2008) 3.Im, D.-S., Clemens, J., Macdonald, T.L., et al.Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptorsBiochemistry40(46)14053-14060(2001) 4.Meyer zu Heringdorf, D., Himmel, H.M., and Jakobs, K.H.Sphingosylphosphorylcholine-biological functions and mechanisms of actionBiochim. Biophys. Acta1582(1-3)178-189(2002) 5.Rodriguez-Lafrasse, C., and Vanier, M.T.Sphingosylphosphorylcholine in Niemann-Pick disease brain: Accumulation in type A but not in type BNeurochem. Res.24(2)199-205(1999)