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ly3039478 monohydrate

" in TargetMol Product Catalog.
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  • Crenigacestat
    LY3039478
    T36331421438-81-4
    Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
    • $56
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