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By Target- BACE
- Beta-Secretase(1)
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Results for "
ly2886721
" in TargetMol Product Catalog- Inhibitors & Agonists2
LY 2886721 Hydrochloride
T376611262036-49-6
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.
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