liposomes

Phosphatidylcholines,soya (Soybean phosphatidylcholine) is a phosphatidylcholine from soybean used in the preparation of liposomes.

Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor

1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is a cylindrical-shaped lipid used to synthesize liposomes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is the lipid component in the lipid nanoparticle (LNP) system.

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid utilized in liposomes for the study of lipid monolayers and bilayers.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Palmitoyloleoylphosphatidylcholine) is a phospholipid commonly found in cell membranes, with cholesterol compositions ranging from 0 to 60 mol%.

Control Liposomes (PBS) serve as the control liposomes for Clodronate liposomes and do not contain clodronate.

Clodronate liposomes are composed of chlorophosphate salts encapsulated within phospholipid bilayer liposomes, which are selectively ingested by macrophages following systemic administration. Within macrophage lysosomes, phosphatases gradually release the chlorophosphate salts from the liposomal vesicles, leading to their intracellular accumulation. Once a threshold concentration is reached, the accumulation results in irreversible damage to the macrophages and induces apoptosis, making clodronate liposomes a useful research tool for investigating macrophage depletion and immune modulation.

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (D-Mannosamine hydrochloride) is a pharmaceutical compound used in the development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer's patches.

DSPE-PEG-Maleimide (MW 5000) is a functionalized phospholipid derivative commonly used in the construction of liposomes and nanoparticles. Its terminal maleimide group allows for stable chemical conjugation with thiol-containing biomolecules.

AYK004 is an adenosine derivative that functions as a TLR7/8 agonist, enhancing immune responses by activating the TLR signaling pathway. It boasts an optimal hydrophilic-lipophilic balance, improving its loading rate and stability within immunoadjuvant systems like liposomes, and reduces the side effects of these systems during systemic immunization.

Boc-Pro-OMe (Boc-L-proline methyl ester) is a lipid compound utilized in liposome preparation. Liposomes consist of concentric phospholipid bilayer vesicles, which serve as vital components in constructing drug delivery systems for anticancer and anti-infection applications. These systems effectively encapsulate high-polarity water-soluble payloads within the internal aqueous space of the liposome, while lipophilic payloads are integrated into and become part of the lipid bilayer. This compound is particularly effective for delivering antisense oligonucleotides, addressing issues of low cellular uptake and rapid bodily excretion.

(2S)-3-Keto sphinganine (d6:0) ((2S)-3-Keto-C6-dihydrosphingosine) hydrochloride is a lipid compound utilized in the preparation of liposomes. Liposomes, characterized by concentric phospholipid bilayer vesicles, are critical in constructing drug delivery systems for anti-cancer and anti-infection applications. They effectively encapsulate hydrophilic solutes within their aqueous interiors and incorporate lipophilic cargoes into their phospholipid bilayers, making them integral to the bilayer structure. This compound is particularly valuable in delivering antisense oligonucleotides, addressing challenges such as inefficient cellular uptake and rapid loss in the body.

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine (18:0-22:6 PE) is a lipid compound utilized in the preparation of liposomes. Liposomes, forming the central component of concentric phospholipid bilayer vesicles, are pivotal in constructing drug delivery systems for anti-cancer and anti-infection applications. They effectively encapsulate hydrophilic payloads within their aqueous internal spaces, while lipophilic compounds are integrated into and become part of the lipid bilayer. This compound is particularly effective for delivering antisense oligonucleotides, addressing challenges such as inefficient cellular uptake and rapid loss in the body.

NH2-GG-DSPE is a lipid compound utilized in liposome formulation. Liposomes, having concentric phospholipid bilayer vesicles, are crucial components in constructing drug delivery systems for anti-cancer and anti-infection applications. This compound enables the encapsulation of highly polar water-soluble cargoes within the internal aqueous spaces of liposomes, while lipophilic cargoes can integrate into and become part of the lipid bilayers. NH2-GG-DSPE is particularly effective for delivering antisense oligonucleotides, overcoming challenges such as inefficient cellular uptake and rapid loss in the body.

1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine sodium is a lipid compound utilized in the formulation of liposomes. Liposomes, composed of concentric phospholipid bilayer vesicles, serve as integral components in drug delivery systems aimed at oncology and anti-infection treatments. They efficiently encapsulate hydrophilic (highly polar) solutes within their aqueous interior, while lipophilic solutes are integrated into and become part of the lipid bilayer. This compound is particularly effective in delivering antisense oligonucleotides, addressing challenges such as poor cellular uptake and rapid degradation in the body.

DSPE-PEG(2000)-mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs). Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.

DSPE-PEG-OH (MW 6000) is a phospholipid with a hydroxyl-terminated PEG chain. Its hydrophobic tail facilitates the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl end allows for further chemical reactions. DSPE-PEG-OH (MW 6000) can be utilized to prepare liposomes or lipid nanoparticles, offering potential applications in drug delivery studies and enhancing drug absorption research.

DSPE-PEG-OH (MW 10000) is a hydroxyl-terminated PEGylated phospholipid, with its hydrophobic tail enabling the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl end allows for further reaction. This compound can be used to prepare liposomes or lipid nanoparticles, which are valuable for research in drug delivery and enhancing drug absorption.

DSPE-PEG-OH (MW 8000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail facilitates the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl terminus allows for further reactions. DSPE-PEG-OH (MW 8000) can be used in the formulation of liposomes or lipid nanoparticles for research in drug delivery and enhancement of drug absorption.

DSPE-PEG-OH (MW 4000) is a hydroxy-terminated PEGylated phospholipid with a hydrophobic tail that enables the encapsulation and aggregation of other hydrophobic drugs. The hydroxyl end allows for further reactions. DSPE-PEG-OH (MW 4000) is suitable for the preparation of liposomes or lipid nanoparticles and can be used in studies related to drug delivery and absorption enhancement.

16:0 DGS (1,2-Dipalmitoyl-sn-glycero-3-succinate) can be used in the preparation of pH-sensitive liposomes.

Decylene glycol is used as an antimicrobial agent in cosmetics. It also suppresses the fluidity of the hydrophobic and hydrophilic groups in the phospholipid membrane of liposomes.

MMG-1, a monoalkylglycerol, acts as a C-type lectin receptor agonist and stabilizes lipid membranes. It functions as an immune adjuvant in liposomes and is useful in formulating lipid nanoparticles for drug delivery.