liposomes

Phosphatidylcholines,soya (Soybean phosphatidylcholine) is a phosphatidylcholine from soybean used in the preparation of liposomes.

1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is a cylindrical-shaped lipid used to synthesize liposomes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is the lipid component in the lipid nanoparticle (LNP) system.

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Palmitoyloleoylphosphatidylcholine) is a phospholipid commonly found in cell membranes, with cholesterol compositions ranging from 0 to 60 mol%.

Control Liposomes (PBS) serve as the control liposomes for Clodronate liposomes and do not contain clodronate.

Clodronate liposomes are composed of chlorophosphate salts encapsulated within phospholipid bilayer liposomes, which are selectively ingested by macrophages following systemic administration. Within macrophage lysosomes, phosphatases gradually release the chlorophosphate salts from the liposomal vesicles, leading to their intracellular accumulation. Once a threshold concentration is reached, the accumulation results in irreversible damage to the macrophages and induces apoptosis, making clodronate liposomes a useful research tool for investigating macrophage depletion and immune modulation.

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

DSPE-PEG(2000)-mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs). Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.

DSPE-PEG-OH (MW 6000) is a phospholipid with a hydroxyl-terminated PEG chain. Its hydrophobic tail facilitates the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl end allows for further chemical reactions. DSPE-PEG-OH (MW 6000) can be utilized to prepare liposomes or lipid nanoparticles, offering potential applications in drug delivery studies and enhancing drug absorption research.

DSPE-PEG-OH (MW 10000) is a hydroxyl-terminated PEGylated phospholipid, with its hydrophobic tail enabling the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl end allows for further reaction. This compound can be used to prepare liposomes or lipid nanoparticles, which are valuable for research in drug delivery and enhancing drug absorption.

DSPE-PEG-OH (MW 8000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail facilitates the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl terminus allows for further reactions. DSPE-PEG-OH (MW 8000) can be used in the formulation of liposomes or lipid nanoparticles for research in drug delivery and enhancement of drug absorption.

DSPE-PEG-OH (MW 4000) is a hydroxy-terminated PEGylated phospholipid with a hydrophobic tail that enables the encapsulation and aggregation of other hydrophobic drugs. The hydroxyl end allows for further reactions. DSPE-PEG-OH (MW 4000) is suitable for the preparation of liposomes or lipid nanoparticles and can be used in studies related to drug delivery and absorption enhancement.

16:0 DGS (1,2-Dipalmitoyl-sn-glycero-3-succinate) can be used in the preparation of pH-sensitive liposomes.

Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic analog of the mycobacterial cord factor trehalose 6,6-dibehenate (TDB). DDA has also been used in the study of lipid bilayer dynamics.

C22 Ceramide (d18:1/22:0) (C22 Ceramide), a long-chain ceramide containing behenic acid, is an endogenous bioactive sphingolipid.C22-Ceramide specifically inhibits MCSR and reduces C16 ceramide channel formation in isolated rat liver mitochondria and liposomes.

DSPE-MPEG2000 is a phospholipid–PEG conjugate possessing both hydrophilic and hydrophobic characteristics. DSPE-PEG(2000) is widely utilized in liposome formulation to enhance aqueous dispersion, surface hydration, and in vivo circulation time. DSPE-PEG(2000) supports the development of long-circulating liposomal drug-delivery systems and is frequently applied in preclinical studies involving anticancer and antimalarial therapeutic agents.

NHS-PEG1-SS-PEG1-NHS is a reversible linker used for interacting biomolecules with active small molecules and is effective for linking protein liposomes or nanoparticles (NHS-PEG1-SS-PEG1-NHS).

DPhPC is a synthetic liposome used to synthesize liposomes commonly used in artificial membrane matrices.DPhPC bilayers do not allow ion leakage in the absence of pore/ion channels.DPhPC can be used to study channel proteins and membrane structure.

DSPE-PEG-Maleimide (MW 2000) is a PEG compound which composed of DSPE and maleimide groups. DSPE-PEG-Maleimide (MW 2000) can be used for compose liposomes [1] .

DSPE-PEG Carboxylic Acid Sodium (MW 2000), a PEG-lipid, facilitates the formation of micelle nanoparticles for drug delivery and extends the blood circulation time of liposomes [1].

DSPE-mPEG-2000, a PEG-based phospholipid, facilitates the synthesis of liposomes for cancer agent delivery [1] [2].

18:1 EPC chloride is a cationic alkylated phospholipid and phosphatidylcholine, which can be used in liposome research for drug delivery.

14:0 EPC chloride, an acyl cationic lipid, is utilized in the formation of liposomes for drug delivery applications [1].

16:0-18:1 EPC chloride, a cationic lipid, is utilized in the formation of liposomes for drug delivery applications [1].

DOBAQ, a pH-sensitive cationic lipid, is utilized in the formulation of liposomes for drug delivery applications [1].