linker,bcl-xl

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

(S,R,S)-AHPC-Me-C7 ester is an E3 ligase ligand-linker conjugate used to synthesize BCL-XL PROTAC degraders[1].

N-Boc-SBP-0636457-OH is a ligand for the E3 ubiquitin ligase, facilitating the recruitment of the IAPE3 ligase for the degradation of Bcl-xL. It can be linked to a Bcl-xL ligand via a linker to form PROTACBcl-xLdegrader-1.

N-Boc-SBP-0636457-OH is a synthetic compound that acts as an E3 ligase ligand conjugate, incorporating an IAP ligand and a linker. This compound is utilized in the design of PROTAC Bcl-xL degrader-1.

BCL-xLligand 2 is a ligand for BCL-xL. It can be conjugated with an E3 ligase ligand and a linker to form the Bcl-xL-targeting PROTAC degrader PZ671.

Dioxopiperidin-phthalimidine-PEG3-NBoc is an E3 ligase ligand and linker conjugate (E3 ligase Ligand-Linker Conjugate). It is utilized in the synthesis of the PROTAC protein degrader PZ671, which targets Bcl-xL for degradation.

Pomalidomide-C7-COOH is a synthetic E3 ligase cereblon ligand-linker conjugate characterized by a seven-carbon carboxylic acid linker attached to the pomalidomide moiety. It is a key intermediate for the research and synthesis of PROTAC BCL-XL degraders. This compound is for scientific research use only and not for use in patients.

PROTAC Bcl-xL degrader-1 is a potent PROTAC composed of a Bcl-xL (Bcl-2 family member) ligand-binding group, a linker, and an IAP E3 ligases binding group, demonstrating effectiveness as a Bcl-xL degrader. It exhibits toxicity towards human platelets and MyLa 1929 cells, with IC50 values of 62 nM and 8.5 μM, respectively [1].

Compound 72-1, also known as BCL-xL/BCL-2 ligand 1, serves as a ligand for BCL-xL and BCL-2 proteins. It can be tethered to an E3 ligase via a linker, facilitating the formation of PROTACs [1] [2].