linearmycin b

Linearmycin B is a polyene antibiotic that has been found inStreptomyces.1It induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2 1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiotics: LinearmycinsJ. Chem. Soc., Perkin Trans. 1182315-2319(1996) 2.Stubbendieck, R.M., and Straight, P.D.Escape from lethal bacterial competition through coupled activation of antibiotic resistance and a mobilized subpopulationPLoS Genet.11(12)e1005722(2015)

Linearmycin A is a polyene antibiotic found in [Streptomyces]. It exhibits activity against bacteria [S. aureus] and [E. coli] (MICs = 3.1 and 1.6 μg disc, respectively), fungi [S. cerevisiae] and [C. albicans] (MICs = 0.1 and 1.6 μg disc, respectively), and the plant pathogenic fungus [A. niger] (MIC = 0.2 μg disc) in disc assays. Linearmycin A also induces lysis and degradation of [B. subtilis] as a component of [Streptomyces Mg1] extract.