kos 1584

KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump.

CB-892 is a novel inhibitor of hiv-1 gene expression

cis-9,10-Dehydroepothilone D (KOS-1584) is an epoxide derivative with antiproliferative properties and activity in tubulin polymerization. This compound is useful in the study of lung cancer, colon cancer, prostate cancer, and breast cancer.

Dehydelone(KOS-1584, R-1645, SK-10088) is a microtubule stabilizer that may be used in the treatment of non-small cell lung cancer.