kir4.1

VU6036720 is a potent and selective inhibitor of the isomeric Kir4.1/5.1.VU6036720 inhibits Kir4.1/5.1 activity by decreasing the channel open-circuit probability and single-channel current amplitude.

VU0134992 hydrochloride is the first subtype-preferring, orally active and selective blocker of the Kir4.1 potassium channel pore (IC50: 0.97 μM).

VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM

Kir4.1-IN-1 (Compound 37) is a potent and selective Kir4.1 inhibitor that can cross the blood-brain barrier, with an IC50 of 0.19 μM. It exhibits a rapid-onset antidepressant effect.

ML133 hydrochloride (ML133 HCl) is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibi

VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1.

VU6036720 hydrochloride is a potent, specific inhibitor of Kir4.1/5.1 channels, demonstrating an IC50 value of 0.24 μM in vitro. It is utilized in the research of brain and kidney functions.