kibdelone a

Kibdelone A, a natural heterocyclic polyketide, was first isolated from the soil actinomycete Kibdelosporangium. It exhibits potent and selective cytotoxicity against various human tumor cell lines, in addition to showing significant antibacterial and nematocidal activity.

Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.