Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Tag
  • C-6xHis
    (1)
TargetMol | Tags By Expression System
  • HEK293 Cells
    (1)
TargetMol | Tags By Species
  • Human
    (1)
TargetMol | Tags By SPR-compatible Buffer
  • Buffer exchange required
    (1)
Filter
Search Result
Results for "

kiaa-0070

" in TargetMol Product Catalog
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
TargetMolTargetMolCompare
KARS Protein, Human, Recombinant (His)
Lysyl-tRNA Synthetase, LysRS, Lysine--tRNA Ligase, KIAA0070, KARS
TMPJ-01122
Lysine-tRNA ligase, also known as Lysyl-tRNA synthetase, LysRS, KARS and KIAA0070, belongs to the class-II aminoacyl-tRNA synthetase family. The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain, which is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. KARS catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Defects in KARS are the cause of Charcot-Marie-Tooth disease recessive intermediate type B (CMTRIB).
  • Inquiry Price
7-10 days
Size
QTY