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(2)
By Target- JAK
- Apoptosis(1)
- STAT(1)
- Others(1)
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- Bradykinin Receptor
- cAMP
- Cannabinoid Receptor
- CaSR
- CGRP Receptor
- cholecystokinin
- CRFR
- CXCR
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- EBI2/GPR183
- Endothelin Receptor
- GHSR
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- GNRH Receptor
- GPCR19
- GPR
- GRK
- GTPase
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Results for "
jakin4
" in TargetMol Product Catalog- Inhibitors & Agonists2
JAK-IN-40
T205062
JAK-IN-40 (Compound 46) is an inhibitor of JAK, effectively targeting JAK1, JAK2, and JAK3 with IC50 values of 0.022, 0.759, and 1.601 μM, respectively. It reduces the phosphorylation of STAT3 and inhibits the proliferation of cancer cells Ba/F3 and JAK1-TEL Ba/F3 with GI50 values of 0.614 μM and 0.193 μM. JAK-IN-40 arrests cell cycle progression at the G2/M phase in H1975 and H2087 cells, leading to apoptosis. Additionally, JAK-IN-40 exhibits a synergistic anti-tumor effect when used in combination with Osimertinib.
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