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  • IRE1
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Results for "

ire1/xbp1s

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  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
MKC8866
T155941338934-59-0
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
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IXA6
T625681021106-40-0
IXA6, a novel IRE1 XBP1s agonist with potential vasoprotective activity, activates IRE1-XBP1s signaling and XBP1s transcriptional response, making it useful for studying neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
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6-8 weeks
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IXA4
T93491185329-96-7
IXA4 is a highly selective, nontoxic activator of IRE1 XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.
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