insecticidal

Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

Dodecamethylpentasiloxane can be used as a bed bug insecticide. Dodecamethylpentasiloxane is a component of siloxane and can be used as silicone oil.

piperitone is a natural compound from Piper nigrum L

L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.

α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.

Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.

Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein. Insecticidal agent 364 has antitumor activity, and by inhibiting mTOR, Insecticidal agent 364 aims to disrupt signaling pathways involved in cancer cell growth and survival, thereby potentially inhibiting tumor growth.

Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg mL respectively.

Insecticidal agent 18 (compound 34) is an effective insecticide. It exhibits acaricidal activity.

Insecticidal agent 17 (compound 31) is a pesticide with an LC50 value of 0.759 mg mL against the diamondback moth.

Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folate metabolic pathway. This compound also inhibits the promastigote and amastigote forms of Leishmania major, with IC50 values of 1.43 μM and 3.78 μM, respectively.

Insecticidal agent 20 (Compound 17) is an insecticide that binds to AChBP. It demonstrates effective insecticidal activity against mosquito larvae (LC50: 1.57 ppm) and pupae (LC50: 4.17 ppm).

Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.

Insecticidal agent 22 (Compound A13) is an insecticide with LC50 values of 1.4 and 9.9 μg/mL against Plutella xylostella and Spodoptera frugiperda, respectively. It serves as a low-toxicity alternative to Fluralaner.

Insecticidal agent 24 is an orally active pyridinyl spiroindoline lead compound. It demonstrates antimalarial activity with Pf NF54IC50 of 0.08 μM. Insecticidal agent 24 also inhibits hERG activity with an IC50 of 6.5 μM. In a humanized immunodeficient NSG mouse model of malaria infection, it effectively reduces parasitemia.

Insecticidal agent 23 (compound 17) possesses anti-schistosomal properties with low toxicity. It exhibits strong in vitro activity against adult Schistosoma japonicum, with an LC50 (72 h) value of 25.31 μM.

Insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].

Compound IA-8, an aryl isoxazoline derivative, exhibits insecticidal efficacy against M. separate [1].

Insecticidal Agent 3, a multichitinase inhibitor and part of the insect growth regulators (IGRs) group, exhibits strong inhibition with Ki values of 0.8 μM, 11.9 μM, and 2.3 μM against Of ChtI, Of ChtII, and Of Chi-h enzymes, respectively. It demonstrates effective insecticidal activity against two lepidopteran pests by disrupting insect growth and molting processes [1].

Insecticidal agent 1 exhibits greater insecticidal potency than both obacunone and toosendanin.

Insecticidal Agent 7 (Compound 21m) is an insecticide that acts on insect ryanodine receptors (RyRs), exhibiting a potency with a LC 50 of 0.0937 mg L against Plutella xylostella. It demonstrates significant selectivity and minimal toxicity toward non-target organisms [1].

Insecticidal Agent 10 (Compound 8c) serves as a chitinase inhibitor, effectively targeting OfChi-h and OfChtI with IC 50 values of 1.51 and 9.21 nM, respectively. Additionally, it restricts the growth of Ostrinia furnacalis, exhibiting an LC 50 of 22.14 mg/L.

Epsilon-momfluorothrin (Momfluorothrin, (Z,1R,3R)-), a type I synthetic pyrethroid insecticide, exerts its insecticidal properties and triggers activation of the constitutive androstane receptor (CAR). Notably, its administration in rats has been observed to induce the development of hepatocellular tumors.