imidazo[1,2 b]pyridazine

Imidazo[1,2-b]pyridazine, with CAS No. 766-55-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Imidazo[1,2-b]pyridazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Antifungalagent 108 (compound 14d) is an original imidazo[1,2-b]pyridazine derivative that exhibits potent antifungal activity against Madurella mycetomatis (MM55 strain) with an IC50 of 0.9 μM. The compound shows an IC50 of 14.3 μM for cell viability in NIH-3T3 mouse fibroblasts.