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By Target- Ferroptosis
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Results for "
ifsp1
" in TargetMol Product Catalog- Inhibitors & Agonists2
iFSP1
T11631150651-39-1
iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RSL3. It uniquely triggers ferroptosis in GPX4-knockout cells overexpressing FSP1.
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viFSP1
Versatile Inhibitor of Ferroptosis Suppressor Protein 1
T84823951945-67-8
viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].
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