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(3)
By Target- Dehydrogenase
- Isocitrate Dehydrogenase (IDH)(1)
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Results for "
idh1 mutants r132c
" in TargetMol Product Catalog- Inhibitors & Agonists3
GSK864
GSK 864, GSK-864
T154421816331-66-4
GSK864 is an IDH1 mutant inhibitor that inhibits IDH1 mutants R132C, R132H, and R132G, and is used in the study of cardiovascular and oncology diseases.
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AGI-5198
IDH-C35
T21041355326-35-0
AGI-5198 (IDH-C35) is a potent and selective inhibitor of IDH1 R132H and R132C mutants, with IC50 values of 0.07 μM and 0.16 μM, respectively.
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Crelosidenib
Mutant IDH1-IN-6, LY3410738, LY 3410738
T397162230263-60-0
Crelosidenib is a potent and selective mutant IDH inhibitor with IC50s of 6.27 nM, 3.71 nM, 36.9 nM, and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutases, respectively, and low inhibitory activity against the wild-type IDH enzyme.
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