human calpains 1,2

Alicapistat (ABT-957) is an inhibitor of human calpain 1 and calpain 2. Alicapistat (ABT-957) has been investigated in the context of Alzheimer's disease research. The selective inhibition of calpain proteases by Alicapistat (ABT-957) supports its application in studies of neurodegeneration, proteolytic signaling pathways, neuronal injury mechanisms, and calpain-associated cellular processes.

(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, showing promise for Alzheimer's disease (AD) therapy [1]. It effectively addresses the metabolic liability associated with carbonyl reduction and demonstrates potent inhibition of calpain 1 with an IC50 value of 395 nM [2].