hset

AZ82 is a selective inhibitor of kinesin-like protein KIFC1 (HSET KIFC1), with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.

CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.

Solidagonic acid, by inhibiting HSET motor activity, promotes the conversion of abnormal monopolar spindles to bipolar configurations, effectively suppressing fission yeast cell death and facilitating the mitotic spindles' reversion from monopolar to bipolar morphology. Additionally, this compound demonstrates growth inhibitory effects on the seedlings of Lactuca sativa L. and Lolium multiflorum Lam [1] [2].

Kolavenic acid analog (KAA) is a compound with anticancer activity that demonstrates potent efficacy against HSET-overproducing yeast cells and inhibits centrosome clustering in human cancer cells with supernumerary centrosomes and elevated HSET levels.