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(2)
By Target- Epigenetic Reader Domain
- Apoptosis(1)
- Histone Methyltransferase(1)
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Results for "
hoxa9 expression
" in TargetMol Product Catalog- Inhibitors & Agonists2
MI-2-2
MI22, MI 2 2
T280361454920-20-7
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
- $58
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Menin-MLL inhibitor MI-2 dihydrochloride
T211697
Menin-MLL inhibitor MI-2 dihydrochloride is a competitive and selective inhibitor of the Menin-MLL interaction, with an IC50 value of 446 nM and a Ki value of 158 nM. It reduces the expression of target genes such as HOXA9 and MEIS1, inhibits the proliferation of leukemic cells, and induces apoptosis and differentiation. Menin-MLL inhibitor MI-2 dihydrochloride shows potential for research in MLL-rearranged acute leukemias, such as acute myeloid leukemia and acute lymphoblastic leukemia.
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