hnrnpk-in-1

hnRNPK-IN-1 is a specific ligand that binds to the heterogeneous nuclear ribonucleoprotein K (hnRNPK) with high affinity, as evidenced by dissociation constant (Kd) values of 4.6 μM and 2.6 μM determined using surface plasmon resonance (SPR) and microscale thermophoresis (MST), respectively. This binding disrupts the interaction between hnRNPK and the c-myc promoter, thereby inhibiting c-myc transcription. Furthermore, hnRNPK-IN-1 induces apoptosis in HeLa cells and exhibits significant anti-tumor activity.