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By Target- Apoptosis
- Interleukin(1)
- STAT(1)
- TGF-beta/Smad(1)
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Results for "
hjc-0123
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- HJC-0123T706861430420-02-2Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
- $1,520
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