hiv1 inhibitor3

HIV-1 inhibitor-3 is an HIV infection inhibitor.

HIV-1 inhibitor-36 (Compound 2) is a potent HIV-1 inhibitor with significant potential as a novel latency-reversing agent [1].

HIV-1 inhibitor-37 (Compound 83) is a potent HIV-1 inhibitor with significant potential as an innovative latent HIV-1 reactivating agent [1].

HIV-1 inhibitor-30 (compound 10i) is a potent inhibitor of HIV-1, specifically targeting the RT DNA polymerase enzyme, showing strong antiretroviral activity with an EC50 value of 40 nM and an IC50 value of 80 nM. Moreover, it demonstrates significant effectiveness against seven NNRTI-resistant strains of HIV-1 (RT-K103N; RT-Y181C; RT-K103N, Y181C; RT-L100I, K103N; RT-Y188L; RT-K103N, G190A; RT-K103N, V108I), with IC50 values from 0.04 to 1.42 μM. This compound holds potential for AIDS research [1].

HIV-1 inhibitor-38 (Compound 91) is a potent HIV-1 activity inhibitor and shows significant potential as a novel latency reversing agent, making it a promising candidate for further development [1].

HIV-1 inhibitor-35 (compound 74) is a highly potent inhibitor of the HIV-1 virus, exhibiting EC50 values of 80 nM and 70 nM for LTR and CMV, respectively, in HEK293 cells. Additionally, it demonstrates inhibitory activity against HepG2 liver cancer cells, with a CC50 value of 40 nM, and shows promise as a potential HIV-1 latency reversing agent [1].

HIV-1 inhibitor-31 (compound 4) is a potent inhibitor of HIV-1 and can be used in the study of AIDS.

HIV-1 inhibitor-33 (compound 5n) is a potent and selective HIV-1 inhibitor with an EC50 of 8.6 nM and a CC50 of 18 μM in MT-4 cells, and can be used in the study of AIDS.

HIV-1 inhibitor-34 (compound 5q) is a potent and selective HIV-1 inhibitor, with an EC50 of 6.4 nM for HIV-1 and a CC50 of 16 μM in MT-4 cells, making it useful for AIDS research.

HIV-1 inhibitor-32 is a potent inhibitor of HIV-1 that acts on wild-type HIV (IC50: 34 nM) and can be used in AIDS research.

HIV-1 inhibitor-39 is a potent inhibitor of HIV-1 (EC50>112.88 μM). HIV-1 inhibitor-39 has anti-RT (HIV-1 reverse transcriptase) effect (IC50: 15.75 μM). HIV-1 inhibitor-39 exhibits cytotoxicity against MT-4 cells (CC50: 112.9 μM).