hhdac6

HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.

CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, HDAC 9, and can be used in cancer research.

HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.

Trichostatin A S-isomer is the s-isomer of Trichostatin A. Trichostatin A is a histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Trichostatin A inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20

HDAC10-IN-2 (compound 10c) is a potent and highly selective HDAC10 inhibitor (IC50 = 20 nM) that regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1].

HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor (IC50 = 58 nM) that regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1].

HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor with IC50 values of 0.27 μM and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. It effectively kills schistosome larvae and significantly reduces egg laying in adult worm pairs [1].

Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.

T-518, an orally active and selective HDAC6 inhibitor with an IC50 value of 36 nM for human HDAC6, can permeate the blood-brain barrier and is applicable in tauopathy research [1].