gw642444

Vilanterol is a selective long-acting beta2-adrenergic agonist (LABA) used in the treatment of COPD and asthma.

Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively)

VILANTEROL α-PHENYL CINNAMATE (GW642444H) is a long-acting β2-adrenergic receptor agonist used once daily for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

Vilanterol (GW642444) acetate is a long-acting β2-AR agonist. The pEC50 values for vilanterol acetate are 9.4 for β2-AR, 6.4 for β1-AR, and 6.1 for β3-AR, indicating its selectivity in activating airway β2-AR receptors. This activation elevates cAMP levels, resulting in the relaxation of bronchial smooth muscle. Vilanterol acetate can be used in asthma-related research.