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Results for "
gsk 484
" in TargetMol Product Catalog- Inhibitors & Agonists2
GSK484 hydrochloride
Cited
GTPL8577, AOB6992
TQ00671652591-81-5
GSK484 hydrochloride (GTPL8577) is a reversible peptidyl-arginine deiminase 4 (PAD4) inhibitor. It binds to PAD4 with high affinity, with IC50 of 250 and 50 nM in the presence and absence of 2 mM calcium, respectively. GSK484 promotes the radiosensitivity of colorectal cancer (CRC) and inhibits NET formation in vitro and in vivo.
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