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(2)
By Target- Apoptosis
- MAPK(2)
- ASK(1)
- Others(2)
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By Target By ResearchField- Cancer(1)
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Results for "
gs 4997
" in TargetMol Product Catalog.- Inhibitors & Agonists3
- SelonsertibGS-4997T33501448428-04-3Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
- $33
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Cited - Selonsertib HClT706221448428-05-4Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
- $1,970
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