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By Target- Epigenetic Reader Domain
- PROTACs(1)
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Results for "
gne987
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- PROTAC Products2
- GNE-987GNE987, GNE 987T114412417371-71-0GNE-987 is a highly active chimeric BET degrader that binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low-nanomolar affinity and induces exceptionally potent BRD4 degradation in cells, achieving picomolar DC50 values in EOL-1 acute myeloid leukemia cells, thereby serving as a powerful chemical biology tool for dissecting BET-dependent transcriptional regulation.
- $243
SizeQTY - (S)-GNE-987T12798(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
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