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gne 783

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  • Inhibitors & Agonists
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    TargetMol | All_Pathways
GNE-783
GNE783
T274241200127-66-7
GNE-783 is a highly selective CHK1 inhibitor that effectively enhances the antitumor efficacy of gemcitabine. After DNA damage, it inactivates S-phase and G2-phase cell cycle checkpoints, thereby improving the therapeutic effect of antimetabolite DNA-damaging agents. GNE-783 shows selective chemosensitization in different tumors, such as enhancing the antitumor activity of temozolomide only in melanoma cell lines.
  • $1,520
1-2 weeks
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