gdc 0199

Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48 245 nM). Venetoclax induces autophagy and apoptosis.

Venetoclax-d8 (ABT-199-d8) is a deuterated form of Venetoclax, a potent, selective, and orally active Bcl-2 inhibitor that induces autophagy and apoptosis.

Venetoclax N-oxide is an impurity of Venetoclax, a highly potent, selective, and orally bioavailable inhibitor of Bcl-2, with a Ki value of less than 0.01 nM (ABT-199; GDC-0199) [1].