gastric mucosa

Pentagastrin (ICI-50123) is a synthetic polypeptide that mimics the effects of gastrin when administered parenterally, influencing the secretion and synthesis of salivary proteins.

CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa.

Spizofurone (Espizofurona) has antiulcer activity, protective effect on the gastric mucosa of rats, and can increase alkaline secretion in isolated bullfrog duodenal mucosa.

Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.

Esaprazole (C/63) has a dose - dependent cellular protective effect on the human gastric mucosa.

Quinotolast (FK021) is an orally active mast cell stabilizer with cytoprotective properties on the gastric mucosa. It exhibits both antiallergic and antiulcer functions.

Mezolidon (KM-1146) is a compound with anti-ulcer activity that operates by strengthening the defensive mechanisms of the gastric mucosa. It achieves this, in part, by enhancing and sustaining blood flow to the gastric mucosa and by safeguarding the gastric mucosal potential difference. Mezolidon is applicable in research focused on gastric mucosal protection.

Sucrose octasulfate, a sulfated oligosaccharide derivative, functions as an inhibitor of matrix metalloproteinases (MMPs). This compound stimulates somatostatin-like immunoreactivity (SLI) release from the stomach by directly targeting D cells in the gastric mucosa. By releasing endogenous gastric somatostatin, sucrose octasulfate promotes ulcer healing. It serves as a pharmaceutical excipient, significantly enhancing wound closure in neuroischemic diabetic foot ulcers and venous leg ulcers. Additionally, sucrose octasulfate is applicable in research related to chronic wound healing.

S-Diclofenac is a novel NSAID formed by linking diclofenac to an H2S-releasing moiety. S-Diclofenac spares the gastric mucosa of injury despite markedly suppressing prostaglandin synthesis [1].

PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems.

Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury.

Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.

Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule with anti-inflammatory, antioxidant, and gastroprotective effects. It also modulates potassium channels independently of CO.

Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.

Sucrose octasulfate, a constituent of sulfoaluminum, promotes the release of somatostatin-like immunoreactivity (SLI) through direct interaction with D cells within the gastric mucosa, thereby exerting its ulcer-healing effects by facilitating the secretion of endogenous gastric somatostatin. This compound is utilized in anti-gastric ulcer research [1].

Rotraxate (TEI 5103) is a compound with anti-ulcer properties that is effective when taken orally. It enhances blood circulation to the gastric mucosa and supports its structural integrity. Rotraxate is useful for exploring the protective effects of medications on the gastric mucosa, particularly in research focused on preventing or treating gastric ulcers through direct action on the gastric mucosa.

Manassantin A (Standard) is a reference standard for research and analysis in studies involving Manassantin A. Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.

Jujubasaponin VI is a triterpenoid saponin compound found in Zizyphi Fructus, noted for its anti-ulcer activity. Animal studies demonstrate its ability to significantly inhibit stress-induced gastric ulcers, potentially by protecting gastric mucosa and suppressing acid secretion. Jujubasaponin VI is useful in researching digestive system diseases, particularly gastric ulcers and mucosal injury.

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act

6-Gingediol (compound 13) is a pungent component derived from ginger, noted for its potential antiserotonergic properties and protective effects on the gastric mucosa. Notably, 6-Gingediol exhibits no nasal irritation at concentrations below 10 μM, while significantly pronounced nasal irritation occurs at concentrations exceeding 100 μM and up to 1000 μM.

Xenin is a 25 amino acid peptide that has been identified in human gastric mucosa in the search for a counterpart to the amphibian octapeptide xenopsin.