gastric mucin

Gastric mucin, a large glycoprotein, is thought to play a major role in protecting the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma. Gastric mucin is a natural protein derived from pigs.

IQB-782 is a mucolytic agent with mucolytic expectorant activity.IQB-782 inhibits thrombin-activating fibrinolytic inhibitor (TAFI), protects rats from tobacco smoke-induced respiratory obstruction, reduces the viscosity of gastric mucin suspensions in vitro, and may be useful in studies of obstructive lung disease.IQB-782 has been shown to reduce the viscosity of gastric mucin suspensions in vitro.

Anti-MUC17 Antibody is a humanized monoclonal antibody expressed in CHO cells targeting the transmembrane mucin MUC17 (also known as MUC3G). This product specifically recognizes the extracellular domain of MUC17. MUC17 is overexpressed in various gastrointestinal tumors, particularly gastric and colorectal cancers. The antibody binds to MUC17 on the cell surface, mediating antibody-dependent cellular cytotoxicity (ADCC), and serves as a vehicle for the targeted delivery of conjugated therapeutic payloads (as in ADC research) into tumor cells.

N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer enhances the aberrant O-glycosylation of CD44, activating the Wnt/β-catenin signaling pathway and influencing the malignant behavior of gastric cancer cells. This enzyme plays a crucial role in cancer progression and metastasis by modifying the O-glycosylation of various glycoproteins such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3.