gar 936

Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline that binds to the 30S ribosomal subunit, disrupting the binding of aminoacyl-tRNA to the mRNA-ribosome complex.

Tigecycline hydrate (GAR-936 hydrate) is a broad spectrum glycylcycline antibiotic. Tigecycline hydrate is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline hydrate is active against resistant strains of Gram-positive and Gram-negative bacteria .

Tigecycline tetramesylate (GAR-936 tetramesylate), a broad-spectrum glycylcycline antibiotic, exhibits a mean inhibitory concentration (MIC) for E. coli (MG1655 strain) of approximately 125 ng mL [1]. For Acinetobacter baumannii (A. baumannii), the MIC 50 and MIC 90 values stand at 1 and 2 mg L, respectively [2].