g2/m-phase transition

Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, Cyclin E/cdk2, and P35/cdk5 with IC50 of 33 nM, 33 nM, 28 nM and 20 nM, respectively.

CDC25-IN-1 (Compound D11b) is an inhibitor of the cell division cycle 25 (CDC25) phosphatase. It effectively suppresses leukemia and colorectal cancer cells by blocking CDC25-mediated CDK1Tyr15 dephosphorylation, delaying the G2/M phase transition, and inducing caspase-dependent apoptosis and DNA damage. This compound is useful for researching leukemia and colorectal cancer.

BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with an IC50 of 2.3 nM. It induces cell apoptosis by blocking the G2-M phase transition.

9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha