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Results for "
frameshifting
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Recombinant Protein1
Merafloxacin
CI 934
T906691188-00-0
Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.
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4'-(2-(p-Chlorophenyl)acetoxyl)spiramycin
T205021
4 -(2-(p-Chlorophenyl)acetoxyl)spiramycin (Compound 2d) is a broad-spectrum anti-coronavirus agent that targets the frameshifting element (FSE). It inhibits HCoV-OC43 and HCoV-229E with EC50 values of 0.85 μM and 1.45 μM, respectively. This compound exhibits a dual-target mechanism by acting on both viral FSE RNA and host DIS3L2.
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Covidcil-19
T711911225177-95-6
Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
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SARS-CoV-2-IN-91
T88889
SARS-CoV-2-IN-91 (Compound 194) is an inhibitor of SARS-CoV-2, exhibiting an EC50 of 28.92 μM. It inhibits the viruss -1 programmed ribosomal frameshifting (-1PRF) element, thereby suppressing the replication of SARS-CoV2.
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